PRINCIPLES OF GENETICS

 

 

PRINCIPLES OF GENETICS

Code:ZOO-2011

Credit: 3(T)+1(P)

Unit1:

Principles of Inheritance,

        Incomplete Dominance and Co-Dominance

        Multiple Alleles

        Lethal Alleles, Penetrance and Expressivity

        Epistasis

        Pleiotropy

        Sex-Linked Inheritance

        Sex-Influenced and Sex-Limited Characters in Inheritance

        Concept of Gene

        Linkage and Crossing Over

        Cytological Basis of Crossing Over

        Recombination Frequency as a Measure of Linkage Intensity

        Two-Factor and Three-Factor Crosses

         Linkage Map

         Coefficient of Coincidence and Interference

         Gene Mapping by Somatic Cell Hybridization

 

Unit2:

 Mutation

        Gene Mutation

Chromosomal Aberrations—Deletion, duplication, inversion, translocation, aneuploidy and polyploidy 

        Induced vs. Spontaneous Mutations

Backward and Forward Mutations

        Suppressor Mutations

        Molecular Basis of Mutations in Relation to UV Light and Chemical Mutagens

        Detection of Mutations in Drosophila: CLB and Attached Methods

Unit3:                                                                                                                    10

Basis of Sex Determination: Genetic and Environmental 

Sex Determination in Drosophila and Humans

Mechanism of Dosage Compensation

       Comparison of Nuclear and Extranuclear Inheritance

Organelle Inheritance

        Antibiotic Resistance in Chlamydomonas

        Mitochondrial Mutations in Saccharomyces and Human Disorders

        Infective Heredity in Paramecium

        Maternal Effects: Shell Coiling in Limnaea and Pigmentation in Ephestia

        Polygenic Inheritance and Transgressive Variation